Using Human Intestinal Organoids to Model IBD Pathogenesis

Inflammatory bowel disease (IBD) is a chronic disease characterized by intermittent episodes of intestinal inflammation and disruption of the intestinal epithelial barrier. The IBD Genetics Consortium has intensively studied the genetic architecture of this complex disease.

Differential Impact of Smoking on Trancsriptome and Epigenome in Crohn's Disease and Ulcerative Colitis

Biomarking IBD Patient Specific Disease Features Using the Epithelial Antigenic Petidome

In immune-mediated diseases such as type1 diabetes, target-cell autoantibodies have emerged as important clinical biomarkers of pre-clinical disease progression and mechanistic disease subsets. However, with the focus on genetics, inflammatory effectors, and microbiome, there has not been a modern search for such antibody biomarkers and the potential contribution of anti-epithelial autoimmunity in IBD.

Leveraging the Epigenome of Inflammatory Bowel Disease to Gain Mechanistic Insights Into Disease Pathophysiology

Ulcerative colitis (UC) is a chronic relapsing and remitting intestinal inflammatory disorder with a very heterogeneous clinical course. While on life-long maintenance therapy, although most patients achieve complete mucosal healing with no disease activity during the course of treatment of UC, a subgroup (~40%) experience chronically active severe disease with persistent inflammation as reflected by need for escalation of medical therapy or surgery.

Profiling Intraepithelial Lymphocyte Populations in Health and Crohn’s Disease

Immunological surveillance at barrier surfaces is essential to provide defense against enteric pathogens and maintain mucosal homeostasis. Disruption of the balance between pro-inflammatory and regulatory immune response can lead to a loss of mucosal tolerance and development of chronic inflammatory disease, such as Crohn’s disease (CD).

Role of Cytomegalovirus in the Natural History of Crohn’s Disease

Crohn’s disease (CD) is a multifactorial and complex disease, orchestrated by several genetic and environmental triggers. The best known genetic marker for CD is the nucleotide oligomerization domain 2 (NOD2), a cytoplasmic receptor that responds to bacterial pathogens.