R21

Leveraging the Epigenome of Inflammatory Bowel Disease to Gain Mechanistic Insights Into Disease Pathophysiology

Ulcerative colitis (UC) is a chronic relapsing and remitting intestinal inflammatory disorder with a very heterogeneous clinical course. While on life-long maintenance therapy, although most patients achieve complete mucosal healing with no disease activity during the course of treatment of UC, a subgroup (~40%) experience chronically active severe disease with persistent inflammation as reflected by need for escalation of medical therapy or surgery.

Profiling Intraepithelial Lymphocyte Populations in Health and Crohn’s Disease

Immunological surveillance at barrier surfaces is essential to provide defense against enteric pathogens and maintain mucosal homeostasis. Disruption of the balance between pro-inflammatory and regulatory immune response can lead to a loss of mucosal tolerance and development of chronic inflammatory disease, such as Crohn’s disease (CD).

Role of Cytomegalovirus in the Natural History of Crohn’s Disease

Crohn’s disease (CD) is a multifactorial and complex disease, orchestrated by several genetic and environmental triggers. The best known genetic marker for CD is the nucleotide oligomerization domain 2 (NOD2), a cytoplasmic receptor that responds to bacterial pathogens.