R01

Identifying Population Specific IBD Associated Mutations, Genes and Pathways

Inflammatory bowel disease (IBD) is a group of disorders that involve chronic inflammation of the colon and small intestine. The two major types of IBD are ulcerative colitis (UC): long term inflammation and ulcers of the colon and rectum, and Crohn’s Disease (CD): inflammation of the digestive tract lining that can spread into affected tissues.

Functional Molecular Investigation of Inflammatory Bowel Disease (IBD) Risk Variants

Inflammatory bowel disease (IBD) is a chronic disease characterized by intermittent episodes of intestinal inflammation and disruption of the intestinal epithelial barrier. The IBD Genetics Consortium has intensively studied the genetic architecture of this complex disease.

Understanding How a Loss of Epigenetic Reader SP140 Contributes to IBD

Genetics underlie susceptibility to inflammatory bowel disease (IBD) but the rapid rise in incidence, as well as low concordance rates, point to a prevalent role for the environment and possibly the epigenome.

New Computational, Transcriptional, and Genome Editing Approaches to the Biology of Inflammatory Bowel Disease

Over the past decade, the NIDDK IBDGC (Inflammatory Bowel Disease Genetics Consortium) has generated extraordinary datasets in support of genetic analysis of the onset, progression, and therapeutic response to Crohn’s disease and ulcerative colitis.