Talin Haritunians

Latest

• Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease
• Prevalence and Effect of Genetic Risk of Thromboembolic Disease in Inflammatory Bowel Disease
• Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations
• Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease
• Inflamed ulcerative colitis regions associated to MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target
• Ileal Gene Expression Data from Crohn’s Disease Small Bowel Resections Indicate Distinct Clinical Subgroups
• Genetic Markers Predict Primary Nonresponse and Durable Response to Anti–Tumor Necrosis Factor Therapy in Ulcerative Colitis
• Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease
• Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population
• Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics
• Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients
• Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD
• Fine-mapping inflammatory bowel disease loci to single-variant resolution
• Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease
• The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction
• Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway
• A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF
• A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition
• Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis
• Increased Prevalence of Inflammatory Bowel Disease in Patients with Mutations in Genes Encoding the Receptor Subunits for TGFβ
• Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits
• Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans
• Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism
• A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia
• Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients
• Association of NOD2 and IL23R with inflammatory bowel disease in Puerto Rico
• Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease
• Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease
• Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
• Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
• Variants in ZNF365 isoform D are associated with Crohn's disease
• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
• Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
• Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease
• Genome-wide association identifies multiple ulcerative colitis susceptibility loci
• Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand
• Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease