Subra Kugathasan

Latest

• Gene Discoveries in Subjects With Crohn’s Disease of African Descent
• Leveraging the Epigenome of Inflammatory Bowel Disease to Gain Mechanistic Insights Into Disease Pathophysiology
• A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn's disease
• Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease
• Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations
• Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease
• Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort
• Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy
• Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
• Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets
• Dynamics of metatranscription in the inflammatory bowel disease gut microbiome
• Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease
• A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF
• A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition
• Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans
• Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease
• Contribution of higher risk genes and European admixture to Crohn's disease in African Americans
• Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
• Common variants at five new loci associated with early-onset inflammatory bowel disease
• Established genetic risk factors do not distinguish early and later onset Crohn's disease.
• Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease.