Ramnik J. Xavier

Latest

• Functional screen of inflammatory bowel disease genes reveals key epithelial functions
• Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
• C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions
• Dynamics of metatranscription in the inflammatory bowel disease gut microbiome
• Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population
• Fine-mapping inflammatory bowel disease loci to single-variant resolution
• Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
• A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition
• Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo
• Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis
• Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation
• Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst
• Disease-specific alterations in the enteric virome in inflammatory bowel disease
• Genetic polymorphisms in metabolizing enzymes modifying the association between smoking and inflammatory bowel diseases
• Differential effect of genetic burden on disease phenotypes in Crohn's disease and ulcerative colitis: analysis of a North American cohort
• Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease
• Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome
• How does genotype influence disease phenotype in inflammatory bowel disease?
• Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
• Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
• Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients
• Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
• Genome-wide association identifies multiple ulcerative colitis susceptibility loci
• Common variants at five new loci associated with early-onset inflammatory bowel disease
• Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
• Genome-wide association studies: a new window into immune-mediated diseases
• Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis
• Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis