Genetic Research Centers
Data Coordinating Center
Mark S. Silverberg
Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease
Inflamed ulcerative colitis regions associated to MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target
Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort
Persistent Diarrhea in Patients With Crohn's Disease After Mucosal Healing Is Associated With Lower Diversity of the Intestinal Microbiome and Increased Dysbiosis
Genetic effects on the commensal microbiota in inflammatory bowel disease patients
Differential Expression of microRNAs in Peripheral Blood Mononuclear Cells Identifies Autophagy and TGF-Beta-Related Signatures Aberrantly Expressed in Inflammatory Bowel Disease
Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population
Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta-analysis
Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease
Microbiome Heterogeneity Characterizing Intestinal Tissue and Inflammatory Bowel Disease Phenotype
A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF
A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition
Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis
Genetic Predictors of Benign Course of Ulcerative Colitis-A North American Inflammatory Bowel Disease Genetics Consortium Study
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits
Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in Familial and Sporadic Inflammatory Bowel Disease
Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans
Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease
Predictors of Outcome in Ulcerative Colitis
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine
Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
Relationship between proximal Crohn's disease location and disease behavior and surgery: a cross-sectional study of the IBD Genetics Consortium
Contribution of higher risk genes and European admixture to Crohn's disease in African Americans
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2.
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis.
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
Common variants at five new loci associated with early-onset inflammatory bowel disease
Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis
Phenotypic and genotypic characteristics of inflammatory bowel disease in French Canadians: comparison with a large North American repository
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Assessment of reliability and validity of IBD phenotyping within the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) IBD Genetics Consortium (IBDGC).
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease.
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort.
Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus.