Genetic Research Centers
Data Coordinating Center
Mark J. Daly
Functional screen of inflammatory bowel disease genes reveals key epithelial functions
Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease
Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions
Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population
Fine-mapping inflammatory bowel disease loci to single-variant resolution
A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.
A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF
Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.
Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
Common variants at five new loci associated with early-onset inflammatory bowel disease
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
Established genetic risk factors do not distinguish early and later onset Crohn's disease.
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease.
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.