Mark J. Daly

Latest

• Functional screen of inflammatory bowel disease genes reveals key epithelial functions
• Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease
• Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort
• C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions
• Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease
• Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population
• Fine-mapping inflammatory bowel disease loci to single-variant resolution
• A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.
• A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF
• Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis
• Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
• Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation
• Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
• High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
• Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.
• Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
• Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
• Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
• A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
• Genome-wide association identifies multiple ulcerative colitis susceptibility loci
• Common variants at five new loci associated with early-onset inflammatory bowel disease
• Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
• Established genetic risk factors do not distinguish early and later onset Crohn's disease.
• Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
• Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
• Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
• Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease.
• A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.