Clara Abraham

Latest

• Functional Outcomes of Common and Rare IBD Associated Variants
• IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes
• IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome
• Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets
• A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF
• Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
• A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci
• Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
• A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.